pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers improve level of toremifene metabolism, reducing the steady-point out focus in serum.fentanyl transmucosal and pentobarbital both boost sedation. Steer clear of or Use Alternate Drug. Restrict use to clients fo